Vitamin K2 is a fat-soluble vitamin that has been has potentiated as one effective therapeutic nutritive supporting the mechanisms of vitamin D and maintaining bone mineral density. Although Vitamin K2 has been long studied as a vitamin necessary for clotting factors, its MK-7 form has been found to be the most bioavailable and contribute to assist in the process of bone remineralization.
A study by Huang, et al., (2014) was compiled to identify the role of Vitamin k2 in the prevention and treatment of osteoporosis in postmenopausal women. The mechanism of action of vitamin K2 functions to inhibit apoptosis, allowing the number of osteoblasts, osteocalcin, and matrix Gla proteins to be maintained. Therefore, allowing bone remineralization to occur resulting in increased bone mineral density. Results of the study by Huang, et al., (2014) found significant improvements in the vertebral BMD compared to baseline in the osteoporotic groups supplementing with vitamin K as well as osteocalcin, and a reduction in levels of undercarboxylated osteocalcin. Thus, resulting in an increased bone mineral density and reversal or great treatment for osteoporosis. By increasing bone mineral density and osteoblastic activity via mechanisms of Vitamin K2, will also reduce risk of fracture due to stronger bones if an event were to occur .
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References:
Huang, Z.-B., Wan, S.-L., Lu, Y.-J., Ning, L., Liu, C., & Fan, S.-W. (2014, December 4). Does Vitamin K2 Play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. International Osteoporosis Foundation and National Osteoporosis Foudantiion, 1(26), 1175-1186.